Therapy Detail
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| Therapy Name | Cytarabine + Fludarabine + Ziftomenib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cytarabine | Cytosar-U | Ara-C | Cytosar-U (cytarabine) is a cytidine analog that, when incorporated into DNA, inhibits DNA synthesis and repair (PMID: 32524309). | |
| Fludarabine | Fludara | FAMP|Fludarabine phosphate | Flurdara (fludarabine) is converted to 2-fluoro-ara-ATP intracellularly, which potentially inhibits DNA polymerase alpha, ribonucleotide reductase and DNA primase, leading to decreased DNA synthesis and reduced tumor growth (NCI Drug Dictionary) | |
| Ziftomenib | Komzifti | KO539|KO 539|KO-539 | MEN1-KMT2A Inhibitor 8 | Komzifti (ziftomenib) is a small molecule inhibitor of MEN1 (menin)-KMT2A (MLL1) complex, which may lead to decreased growth KMT2A (MLL1)-positive tumor cells, and inhibition of tumor growth (PMID: 36151141). Komzifti (ziftomenib) is FDA-approved for use in patients with relapsed/refractory acute myeloid leukemia harboring a susceptible NPM1 mutation (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06376162 | Phase I | Cytarabine + Fludarabine + Ziftomenib | Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia | Recruiting | USA | NLD | ITA | FRA | ESP | CAN | AUT | 0 |
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