Therapy Detail
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| Therapy Name | ARI0002h |
| Synonyms | |
| Therapy Description |
ARI0002h (cesnicabtagene autoleucel) are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting the B-cell maturation antigen (BCMA) and containing TNFRSF9 (4-1BB) costimulatory and CD3zeta activation domains, which may induce cytotoxicity against tumor cells and inhibit tumor growth (PMID: 31919085, PMID: 37414060). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ARI0002h | ARI-0002h|ARI 0002h|cesnicabtagene autoleucel|ARI2h | TNFRSF17 Immune Cell Therapy 27 | ARI0002h (cesnicabtagene autoleucel) are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting the B-cell maturation antigen (BCMA) and containing TNFRSF9 (4-1BB) costimulatory and CD3zeta activation domains, which may induce cytotoxicity against tumor cells and inhibit tumor growth (PMID: 31919085, PMID: 37414060). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06830733 | Phase II | ARI0002h | Study to Evaluate the Safety and Efficacy of ARI0002h, for the Initial Treatment of Patients With Primary Plasma Cell Leukaemia (GEM-PLASMACAR) | Not yet recruiting | ESP | 0 |
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