Therapy Detail
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| Therapy Name | Bevacizumab + Raludotatug deruxtecan |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bevacizumab | Avastin | VEGF Antibody 15 VEGFR Inhibitor (Pan) 36 | Avastin (bevacizumab) is a monoclonal antibody that binds VEGF and inhibits binding to VEGFR, potentially resulting in decreased tumor growth (PMID: 15136787). Avastin (bevacizumab) is FDA approved for use in colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, cervical carcinoma, and ovarian cancer, and in combination with carboplatin and paclitaxel in epithelial ovarian, fallopian tube, or primary peritoneal cancer (FDA.gov). | |
| Raludotatug deruxtecan | DS 6000a|DS-6000|DS6000a|DS-6000a|R-DXd|MK-5909 | Raludotatug deruxtecan (DS-6000a) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting CDH6 linked to the cytotoxic DNA topoisomerase inhibitor DXd, which binds to CDH6 expressed on tumor cells and potentially induces tumor cell apoptosis and inhibits tumor growth (PMID: 38205802). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06843447 | Phase Ib/II | Pembrolizumab + Raludotatug deruxtecan Carboplatin + Raludotatug deruxtecan Paclitaxel + Raludotatug deruxtecan Bevacizumab + Raludotatug deruxtecan | A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003) | Recruiting | USA | ISR | GBR | ESP | 0 |
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