Therapy Detail
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| Therapy Name | Atebimetinib + Gemcitabine + Nab-paclitaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Atebimetinib | IMM 1-104|IMM1-104|IMM-1-104 | MEK inhibitor (Pan) 27 MEK1 Inhibitor 28 MEK2 Inhibitor 26 | Atebimetinib allosterically inhibits MEK1 and MEK2, potentially resulting in decreased downstream Erk1/2 activation and inhibition of tumor growth (PMID: 42478961). | |
| Gemcitabine | Gemzar | Difluorodeoxycytidine Hydrochlorothiazide|LY-188011 | Chemotherapy - Antimetabolite 14 | Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary). |
| Nab-paclitaxel | Abraxane | ABI-007|Paclitaxel Protein-bound | Chemotherapy - Taxane 3 | Abraxane (nab-paclitaxel) is an albumin-stablized version of paclitaxel, which binds microtubules and prevents depolymerization, resulting in decreased cell motility and division (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07562152 | Phase III | Gemcitabine + Nab-paclitaxel Atebimetinib + Gemcitabine + Nab-paclitaxel | Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma (MAPKeeper 301) | Recruiting | USA | ROU | POL | HUN | GBR | ESP | DEU | AUS | 1 |
| NCT05585320 | Phase Ib/II | Atebimetinib Atebimetinib + Dabrafenib Atebimetinib + Pembrolizumab Atebimetinib + Gemcitabine + Nab-paclitaxel Atebimetinib + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin | A Phase 1/2a Study of IMM-1-104 in Participants With Advanced or Metastatic Solid Tumors | Active, not recruiting | USA | 0 |
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