Therapy Detail
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| Therapy Name | RG6344 |
| Synonyms | |
| Therapy Description |
RG6344 is a paradox-breaking BRAF inhibitor, which potentially decreases tumor growth (Cancer Res (2025) 85 (8_Supplement_2): CT017). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| RG6344 | RO7276389|RG-6344|RG 6344|RO-7276389|RO 7276389 | BRAF Inhibitor 26 | RG6344 is a paradox-breaking BRAF inhibitor, which potentially decreases tumor growth (Cancer Res (2025) 85 (8_Supplement_2): CT017). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E | colorectal cancer | predicted - sensitive | RG6344 | Phase I | Actionable | In a Phase I trial, RG6344 treatment was well tolerated and demonstrated preliminary activity in patients with advanced solid tumors harboring BRAF V600E (n=64), including melanoma (n=11) and colorectal cancer (n=51), with an objective response rate of 25% (Cancer Res (2025) 85 (8_Supplement_2): CT017). | detail... |
| BRAF V600E | melanoma | predicted - sensitive | RG6344 | Case Reports/Case Series | Actionable | In a Phase I trial, RG6344 treatment was well tolerated and demonstrated preliminary activity in patients with advanced solid tumors harboring BRAF V600E (n=64), including melanoma (n=11) and colorectal cancer (n=51), with an objective response rate of 25% (Cancer Res (2025) 85 (8_Supplement_2): CT017). | detail... |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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