Therapy Detail
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| Therapy Name | AB248 + AZD2936 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AB248 | AB-248|AB 248 | AB248 is a fusion protein comprised of an anti-CD8 antibody fused to an IL-2 mutein, which preferentially targets CD8+ T-lymphocytes, potentially resulting in increased antitumor immune response (Cancer Res 2022;82(12_Suppl):Abstract nr 3518). | ||
| AZD2936 | AZD-2936|AZD 2936|Rilvegostomig | PD-L1/PD-1 antibody 132 TIGIT Antibody 20 | AZD2936 is a bispecific antibody that targets T-cell immunoreceptor with immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT) and PD-1 (PDCD1), which potentially leads to increased T-lymphocyte antitumor activity, tumor cell killing, and inhibition of tumor growth (Journal for ImmunoTherapy of Cancer 2022;10). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06996782 | Phase Ib/II | AZD2936 + Cisplatin + Pemetrexed Disodium AZD2936 + Carboplatin + Pemetrexed Disodium AZD2936 + Cisplatin + Pemetrexed Disodium + Ramucirumab AZD2936 + Carboplatin + Paclitaxel AZD2936 + Carboplatin + Nab-paclitaxel + Ramucirumab AZD2936 + Carboplatin + Nab-paclitaxel AZD2936 + Pemetrexed Disodium AZD2936 + Carboplatin + Pemetrexed Disodium + Ramucirumab AB248 + AZD2936 AZD2936 + Carboplatin + Paclitaxel + Ramucirumab | A Platform Study in Non-Small Cell Lung Cancer (NSCLC) (ALTAIR) | Not yet recruiting | USA | TUR | POL | NLD | ITA | FRA | ESP | BRA | BEL | 10 |
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