Therapy Detail
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| Therapy Name | ETX-636 + Fulvestrant |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ETX-636 | ETX636|ETX 636 | PIK3CA inhibitor 27 | ETX-636 selectively inhibits and degrades PIK3CA, with selectivity for mutant forms of PIK3CA, which potentially leads to decreased growth of PIK3CA-mutant tumors (Cancer Res (2025) 85 (8_Supplement_1): 1659). | |
| Fulvestrant | Faslodex | ICI 182,780 | Hormone - Anti-estrogens 31 | Faslodex (fulvestrant) is a competitive inhibitor of estrogen that binds and deforms estrogen receptors, and causes inhibition of growth in cultured estrogen-sensitive breast cancer cells and is FDA approved for use in patients with hormone receptor-positive breast cancer (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06993844 | Phase Ib/II | ETX-636 ETX-636 + Fulvestrant | Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors | Recruiting | USA | 0 |
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