Therapy Detail
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| Therapy Name | ARTS-021 + AVZO-023 + Letrozole |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ARTS-021 | ARTS 021|ARTS021|AVZO-021|AVZO021 | CDK2 Inhibitor 31 | ARTS-021 is a CDK2 inhibitor, which potentially decreases tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 2568). | |
| AVZO-023 | AVZO023|AVZO 023|ARTS023|ARTS 023|ARTS-023 | CDK4 Inhibitor 18 | AVZO-023 (ARTS-023) inhibits CDK4, which potentially induces growth arrest and decreases tumor growth (Cancer Res (2025) 85 (8_Supplement_1): 3026). | |
| Letrozole | Femara | Letrozol | Aromatase Inhibitor 3 | Femara (letrozole) is an aromatase inhibitor, which inhibits estrogen synthesis, and is approved for postmenopausal women with hormone receptor positive breast cancer (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06998407 | Phase Ib/II | AVZO-023 + Fulvestrant ARTS-021 + AVZO-023 + Fulvestrant ARTS-021 + AVZO-023 + Letrozole AVZO-023 + Letrozole | Study of AVZO-023 as a Single Agent and in Combination With AVZO-021, and/or Endocrine Therapy in Advanced Solid Tumors | Recruiting | USA | 0 |
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