Therapy Detail
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| Therapy Name | Abiraterone + ARV-766 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ARV-766 | ARV 766|ARV766|Luxdegalutamide|JSB462 | Hormone - Anti-androgens 57 | ARV-766 is a proteolysis-targeted chimera (PROTAC) that induces degradation of wild-type androgen receptor (AR) and AR ligand-binding domain mutants, which potentially results in antitumor activity (J Clin Oncol 2024 42:16_suppl, 5011). | |
| Abiraterone | Zytiga | CB7630 | Hormone - Anti-androgens 57 | Zytiga (abiraterone) inhibits cytochrome P-450c17, resulting in decreased androgen synthesis (PMID: 25560485). Zytiga (abiraterone) is FDA approved for patients with metastatic castration-resistant prostate cancer (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06991556 | Phase II | Enzalutamide Abiraterone Abiraterone + ARV-766 | An Open-label Study of JSB462 (Luxdegalutamide) in Combination With Abiraterone in Adult Male Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC) | Recruiting | USA | POL | NLD | ITA | FRA | ESP | DEU | CZE | AUS | 3 |
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