Therapy Detail
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| Therapy Name | Onapristone |
| Synonyms | |
| Therapy Description |
Onapristone (ZK299) binds to and inhibits progesterone receptors, potentially resulting in decreased proliferation of progesterone receptor expressing cells (PMID: 32594454). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Onapristone | ZK299|ZK-98299 | Hormone - Anti-progestins 6 | Onapristone (ZK299) binds to and inhibits progesterone receptors, potentially resulting in decreased proliferation of progesterone receptor expressing cells (PMID: 32594454). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04142892 | Phase I | Onapristone | Onapristone as Preoperative Treatment for Postmenopausal Women With Hormone Receptor + and HER2- Breast Cancer (ONAWA) | Completed | ESP | 0 |
| NCT03909152 | Phase II | Onapristone Anastrozole + Onapristone | A Study of Onapristone ER Alone Or In Combination With Anastrozole in Gynecologic Cancers That Respond to Progesterone | Completed | USA | 0 |
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