Therapy Detail
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| Therapy Name | Abiraterone + Ifinatamab deruxtecan |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Abiraterone | Zytiga | CB7630 | Hormone - Anti-androgens 57 | Zytiga (abiraterone) inhibits cytochrome P-450c17, resulting in decreased androgen synthesis (PMID: 25560485). Zytiga (abiraterone) is FDA approved for patients with metastatic castration-resistant prostate cancer (FDA.gov). |
| Ifinatamab deruxtecan | DS7300a|DS 7300a|DS7300|DS 7300|DS-7300|DS-7300a|I-DXd | CD276 Antibody 21 | Ifinatamab deruxtecan (DS-7300a) is a monoclonal antibody targeting B7-H3 (CD276) conjugated to a DNA topoisomerase I inhibitor which may lead to antitumor activities (Ann Oncol (2023) 34 (suppl_2):S481-S482). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06863272 | Phase Ib/II | Ifinatamab deruxtecan Docetaxel Abiraterone + Ifinatamab deruxtecan Enzalutamide + Ifinatamab deruxtecan Ifinatamab deruxtecan + ODM-208 | A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02) | Recruiting | USA | POL | NZL | NLD | ITA | ISR | GBR | FRA | ESP | DEU | CAN | BRA | AUS | ARG | 3 |
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