Therapy Detail
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| Therapy Name | BBI-355 + BBI-825 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BBI-355 | BBI355|BBI 355 | CHK1 Inhibitor 18 | BBI-355 is a selective inhibitor of CHK1, which potentially induces cytotoxicity in tumor cells and antitumor activity (Cancer Res (2024) 84 (6_Supplement): 3631, Ann Oncol (2023) 34 (Suppl_2): S477). | |
| BBI-825 | BBI 825|BBI825 | BBI-825 inhibits ribonucleotide reductase, potentially leading to decreased tumor growth (Mol Cancer Ther (2023) 22 (12_Supplement): B082). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05827614 | Phase I | BBI-355 + BBI-825 BBI-355 + Futibatinib BBI-355 + Erlotinib BBI-355 | Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy, in Subjects With Tumors With Oncogene Amplifications (POTENTIATE) | Recruiting | USA | 0 |
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