Therapy Detail
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| Therapy Name | E-EDV-D682 + EDV-GC + Gemcitabine + Nab-paclitaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| E-EDV-D682 | E-EDV D682|E-EDVD682|Ep-EDV-682 | E-EDV-D682 is an antibody-nanocell conjugate, which delivers the cytotoxic drug PNU-159682 to tumor cells expressing EGFR, potentially resulting in inhibition of tumor growth (PMID: 32183951, PMID: 39373598). | ||
| EDV-GC | ||||
| Gemcitabine | Gemzar | Difluorodeoxycytidine Hydrochlorothiazide|LY-188011 | Chemotherapy - Antimetabolite 14 | Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary). |
| Nab-paclitaxel | Abraxane | ABI-007|Paclitaxel Protein-bound | Chemotherapy - Taxane 3 | Abraxane (nab-paclitaxel) is an albumin-stablized version of paclitaxel, which binds microtubules and prevents depolymerization, resulting in decreased cell motility and division (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07049055 | Phase Ib/II | E-EDV-D682 + EDV-GC + Gemcitabine + Nab-paclitaxel Gemcitabine + Nab-paclitaxel | A Clinical Trial to Evaluate EDV Nanocell Therapy With Gemcitabine and Nab-paclitaxel in Pancreatic Cancer (Carolyn-USA) | Not yet recruiting | USA | 0 |
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