Therapy Detail
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| Therapy Name | NMS-03305293 + Topotecan |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| NMS-03305293 | NMS03305293|NMS 03305293|NMS-293|NMS293|NMS 293 | PARP-1 Inhibitor 13 | NMS-03305293 inhibits PARP1, potentially leading to decreased DNA damage repair, increased tumor cell apoptosis, and inhibition of tumor growth (Mol Cancer Ther (2023) 22 (12_Supplement): LB_A12, NCI Thesaurus). | |
| Topotecan | Hycamtin | Topotecan Hcl | Topotecan binds to topoisomerase I and stablizes complexes with DNA, resulting in decreased repair of DNA single-strand breaks, and potentially leading to cell death (NCI Drug Dictionary). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06930755 | Phase I | NMS-03305293 + Topotecan | Study of NMS-03305293 in Adult Patients With Relapsed Ovarian Cancer | Recruiting | USA | 0 |
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