Therapy Detail
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| Therapy Name | Carboplatin + IMGN151 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Carboplatin | Paraplatin | CBDCA | Chemotherapy - Platinum 7 | Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary). |
| IMGN151 | IMGN-151|IMGN 151 | FOLR1-targeted Therapy 24 | IMGN151 is an antibody-drug conjugate (ADC) comprising an anti-FOLR1 (FRalpha) antibody linked to a maytansinoid-derivative, which potentially leads to killing of tumor cells expressing FOLR1 and reduced tumor growth (Cancer Res (2020) 80 (16_Supplement): 2890). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07024784 | Phase II | Carboplatin + IMGN151 IMGN151 IMGN151 + Olaparib Bevacizumab + IMGN151 | A Study to Assess Change in Disease Activity and Adverse Events in Adult Participants With Gynecologic Cancers Receiving Intravenous Infusion of IMGN151 as Monotherapy or in Combination With Other Therapies | Recruiting | ISR | 1 |
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