Therapy Detail
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| Therapy Name | Lintuzumab-Ac225 + Venetoclax |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Lintuzumab-Ac225 | HuM195-Ac225|Actimab-A|Actinium Ac 225 Lintuzumab | CD33 Antibody 17 | Lintuzumab-Ac225 is an anti-CD33 antibody in conjugation with a radioactive isotope (225Ac) that has anti-leukemia activity (PMID: 24857092). | |
| Venetoclax | Venclexta | ABT-199|RG7601|GDC-0199|ABT119|Venclyxto | BCL2 inhibitor 29 | Venclexta (venetoclax) is a BH3-mimetic that binds to and inhibits BCL2, resulting in increased tumor cell apoptosis (PMID: 26589495, PMID: 25048785). Venclexta (venetoclax) is FDA approved for use in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), and in combination with chemotherapy in patients 75 years old or older with newly-diagnosed acute myeloid leukemia (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03867682 | Phase Ib/II | Lintuzumab-Ac225 + Venetoclax | Venetoclax and Lintuzumab-Ac225 in AML Patients | Unknown status | USA | 0 |
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