Therapy Detail
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| Therapy Name | Giredestrant + RGT-419B |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Giredestrant | RG6171|GDC9545|GDC 9545|GDC-9545) | Hormone - Anti-estrogens 31 | Giredestrant (GDC-9545) is a selective estrogen receptor degrader (SERD) that prevents cell proliferation of ER-positive cells (Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020) 1023-1023). | |
| RGT-419B | RGT419B|RGT 419B|GDC-4198|GDC4198|GDC 4198|RO7840734 | CDK2 Inhibitor 31 CDK4 Inhibitor 18 CDK6 Inhibitor 6 | RGT-419B is a third-generation CDK inhibitor with activity against CDK2, CDK4, and CDK6, which potentially inhibits proliferation of tumor cells and tumor growth (Cancer Res 2021;81(4 Suppl):Abstract nr PS16-22). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07100106 | Phase Ib/II | Abemaciclib + Giredestrant Giredestrant + RGT-419B | A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer | Recruiting | USA | AUS | 0 |
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