Therapy Detail
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| Therapy Name | TJ101 |
| Synonyms | |
| Therapy Description |
TJ101 is an antibody-drug conjugate (ADC) comprising a bispecific antibody targeting EGFR and CD276 (B7-H3) linked to a camptothecin derivative, which potentially induces cytotoxicity in tumor cells expressing EGFR and CD276 (B7-H3) and inhibits tumor growth (Cancer Res (2025) 85 (8_Supplement_1): 2955). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| TJ101 | TJ-101|TJ 101 | CD276 Antibody 22 EGFR Antibody 74 | TJ101 is an antibody-drug conjugate (ADC) comprising a bispecific antibody targeting EGFR and CD276 (B7-H3) linked to a camptothecin derivative, which potentially induces cytotoxicity in tumor cells expressing EGFR and CD276 (B7-H3) and inhibits tumor growth (Cancer Res (2025) 85 (8_Supplement_1): 2955). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07181473 | Phase I | TJ101 | A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patients With Advanced/Metastatic Solid Tumors | Recruiting | USA | 1 |
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