Therapy Detail
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| Therapy Name | OP-3136 + Palazestrant |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| OP-3136 | OP 3136|OP3136 | OP-3136 is a selective KAT6 inhibitor, which potentially inhibits tumor cell proliferation and decreases tumor growth (European Journal of Cancer 211 (2024): 114748). | ||
| Palazestrant | OP1250|OP 1250|OP-1250 | Hormone - Anti-estrogens 31 | Palazestrant is a Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD), which blocks the activity of the AF1 and AF2 domains of the estrogen receptor, potentially resulting in decreased cell proliferation and inhibition of tumor growth (PMID: 38102750). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06784193 | Phase I | Fulvestrant + OP-3136 OP-3136 + Palazestrant OP-3136 | Phase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors | Recruiting | USA | AUS | 0 |
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