Therapy Detail
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| Therapy Name | TROP2 CAR/IL-15 TGFBR2 KO NK cells |
| Synonyms | |
| Therapy Description |
TROP2 CAR/IL-15 TGFBR2 KO NK cells are allogeneic, umbilical cord blood-derived natural killer cells engineered to express a chimeric antigen receptor (CAR) targeting TROP2 and with TGFBR2 deleted, which may lead to enhanced anti-tumor response (NCI Thesaurus). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| TROP2 CAR/IL-15 TGFBR2 KO NK cells | Allogeneic anti-TROP2-CAR-IL-15-transduced TGFBR2-KO CB-derived NKs | TROP2 CAR/IL-15 TGFBR2 KO NK cells are allogeneic, umbilical cord blood-derived natural killer cells engineered to express a chimeric antigen receptor (CAR) targeting TROP2 and with TGFBR2 deleted, which may lead to enhanced anti-tumor response (NCI Thesaurus). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07101432 | Phase I | TROP2 CAR/IL-15 TGFBR2 KO NK cells Cyclophosphamide + Fludarabine | Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK) | Active, not recruiting | USA | 0 |
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