Therapy Detail
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| Therapy Name | Cytarabine + Etoposide + Hydrocortisone + Methotrexate |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cytarabine | Cytosar-U | Ara-C | Cytosar-U (cytarabine) is a cytidine analog that, when incorporated into DNA, inhibits DNA synthesis and repair (PMID: 32524309). | |
| Etoposide | Vepesid | EPEG|Eposin|VP-16|VP-16-213 | TOPO2 inhibitor 5 | Vepesid (etoposide) binds to and inhibits DNA topoisomerase II, resulting in accumulated DNA damage, inhibition of replication, and cell death (NCI Drug Dictionary). |
| Hydrocortisone | Cortisol | |||
| Methotrexate | Abitrexate | Amethopterin | Chemotherapy - Antimetabolite 14 | Methotrexate is an antimetabolite, which inhibits DHFR resulting in decreased immune function and antineoplastic activity and is FDA approved for psoriasis, RA, and several cancers including choriocarcinoma, AML, lung, head and neck and epidermoid (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04293562 | Phase III | Cytarabine + Daunorubicin + Hydrocortisone + Methotrexate Cytarabine + Etoposide + Hydrocortisone + Methotrexate Cytarabine + Hydrocortisone + Methotrexate + Mitoxantrone Cytarabine + Daunorubicin + Gemtuzumab ozogamicin + Gilteritinib + Hydrocortisone + Methotrexate Cytarabine + Daunorubicin + Gemtuzumab ozogamicin + Hydrocortisone + Methotrexate Gilteritinib Asparaginase Erwinia chrysanthemi + Cytarabine Cytarabine + Daunorubicin + Gilteritinib + Hydrocortisone + Methotrexate Cytarabine + Etoposide + Gilteritinib + Hydrocortisone + Methotrexate Cytarabine + Gilteritinib + Hydrocortisone + Methotrexate + Mitoxantrone Asparaginase Erwinia chrysanthemi + Cytarabine + Gilteritinib | A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations | Recruiting | USA | CAN | AUS | 1 |
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