Therapy Detail
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| Therapy Name | 225Ac-ETN029 |
| Synonyms | |
| Therapy Description |
225Ac-ETN029 is a radioconjugate comprising a macrocyclic peptide that binds DLL3 linked to the radionuclide Actinium-225, which potentially induces dose-dependent cytotoxicity and regression of DLL3-expressing tumors (EORTC-NCI-AACR 2024; Abstract nr 152, NCI Thesaurus). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| 225Ac-ETN029 | [225AC]-ETN029|MC339|MC-339|MC 339|ETN 029|ETN-029|225AC-MC339 | DLL3 Inhibitor 1 | 225Ac-ETN029 is a radioconjugate comprising a macrocyclic peptide that binds DLL3 linked to the radionuclide Actinium-225, which potentially induces dose-dependent cytotoxicity and regression of DLL3-expressing tumors (EORTC-NCI-AACR 2024; Abstract nr 152, NCI Thesaurus). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07006727 | Phase I | 225Ac-ETN029 | Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors | Recruiting | USA | CAN | 1 |
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