Therapy Detail
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| Therapy Name | Amcasertib |
| Synonyms | |
| Therapy Description |
Amcasertib (BBI503) is a kinase inhibitor that inhibits signaling pathways that regulate survival of cancer stem cells, resulting in decreased cancer cell growth (NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Amcasertib | BBI-503|BBI503 | Amcasertib (BBI503) is a kinase inhibitor that inhibits signaling pathways that regulate survival of cancer stem cells, resulting in decreased cancer cell growth (NCI Drug Dictionary). |
Filtering
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- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02232620 | Phase II | Amcasertib | A Study of BBI503 in Adult Patients With Advanced Gastrointestinal Stromal Tumors | Terminated | CAN | 0 |
| NCT02432326 | Phase I | Amcasertib Napabucasin | A Study of BBI608 and BBI503 Administered in Combination to Adult Patients With Advanced Solid Tumors | Completed | USA | 0 |
| NCT01781455 | Phase Ib/II | Amcasertib | A Study of BBI503 in Adult Patients With Advanced Solid Tumors | Completed | USA | CAN | 0 |
| NCT02483247 | Phase Ib/II | Paclitaxel Doxorubicin Capecitabine Nivolumab Sunitinib Pembrolizumab Amcasertib | A Study of BBI503 in Combination With Selected Anti-Cancer Therapeutics in Adult Patients With Advanced Cancer | Completed | USA | CAN | 0 |
| NCT02232633 | Phase II | Amcasertib | A Study of BBI503 in Adult Patients With Advanced Hepatobiliary Cancer | Completed | CAN | 0 |
| NCT02432690 | Phase II | Amcasertib | A Study of BBI503 in Asymptomatic Recurrent Ovarian Cancer Patients With CA-125 Elevation | Terminated | USA | 0 |
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