Therapy Detail
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| Therapy Name | Paclitaxel + VVD-130037 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Paclitaxel | Taxol | 7-Epipaclitaxel | Antimicrotubule Agent 14 BCL2 Family Inhibitor 6 | Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary). |
| VVD-130037 | VVD130037|VVD 130037 | VVD-130037 is a small molecule activator of KEAP1, which potentially induces antitumor activity (Cancer Res (2025) 85 (8_Supplement_1): 4349). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05954312 | Phase I | VVD-130037 Paclitaxel + VVD-130037 Pembrolizumab + VVD-130037 Docetaxel + VVD-130037 | A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130037 in Participants With Advanced Solid Tumors | Recruiting | USA | ESP | 1 |
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