Therapy Detail
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| Therapy Name | Fluorouracil + Leucovorin + Oxaliplatin + SGN-CEACAM5C |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Fluorouracil | Adrucil | 5-FU|5-Fluorouracil | Chemotherapy - Antimetabolite 14 | Adrucil (fluorouracil) is an antimetabolite chemotherapeutic agent, which interferes with DNA and RNA synthesis thereby preventing cancer cell growth and is FDA approved for colorectal, breast, stomach, and pancreatic cancer (FDA.gov). |
| Leucovorin | Wellcovorin | Calcium folinate|Calcium citrovorum factor|folinic acid | Chemotherapy - Antimetabolite 14 | Wellcovorin (leucovorin) is a metabolite of folate that enhances the efficacy of fluoruracil (PMID: 32490554). |
| Oxaliplatin | Eloxatin | Diaminocyclohexane Oxalatoplatinum | Chemotherapy - Platinum 7 | Eloxatin (oxaliplatin) is comprised of a platinum complex, which causes DNA-platinum cross-links, inhibition of DNA replication and transcription, and cell toxicity, and is FDA approved for colorectal cancer (FDA.gov). |
| SGN-CEACAM5C | SAR-445953|SAR4 45953|SAR445953|SGN CEACAM5C|PF-08046050 | SGN-CEACAM5C is an antibody-drug conjugate (ADC) comprising a CEACAM5 antibody conjugated to a topoisomerase inhibitor, which potentially inhibits tumor growth (Cancer Res (2024) 84 (6_Supplement): 2118). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06131840 | Phase I | Bevacizumab + SGN-CEACAM5C Bevacizumab + Fluorouracil + Leucovorin + SGN-CEACAM5C Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin + SGN-CEACAM5C Fluorouracil + Leucovorin + Oxaliplatin + SGN-CEACAM5C SGN-CEACAM5C Fluorouracil + Leucovorin + SGN-CEACAM5C | A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors | Recruiting | USA | SWE | NLD | GBR | FRA | ESP | CAN | 0 |
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