Therapy Detail
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| Therapy Name | KITE-753 |
| Synonyms | |
| Therapy Description |
KITE-753 comprises autologous T-lymphocytes manufactured to preserve juvenile T-cells and engineered to express a chimeric antigen receptor (CAR) targeting CD19 containing a CD28 co-stimulatory domain and a CAR targeting CD20 with a 4-1BB co-stimulatory domain, which potentially decrease tumor growth (Blood (2025) 146 (Supplement 1): 704). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| KITE-753 | KITE753|KITE 753 | CD19 Immune Cell Therapy 74 CD20 Immune Cell Therapy 16 | KITE-753 comprises autologous T-lymphocytes manufactured to preserve juvenile T-cells and engineered to express a chimeric antigen receptor (CAR) targeting CD19 containing a CD28 co-stimulatory domain and a CAR targeting CD20 with a 4-1BB co-stimulatory domain, which potentially decrease tumor growth (Blood (2025) 146 (Supplement 1): 704). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04989803 | Phase Ib/II | KITE-753 KITE-363 Cyclophosphamide + Fludarabine | Study of KITE-363 or KITE-753 in Participants With Relapsed and/or Refractory B-cell Lymphoma | Recruiting | USA | NLD | GBR | DEU | AUS | 0 |
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