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Therapy Name SSGJ-707
Synonyms
Therapy Description

SSGJ-707 (PF-08634404) is a bispecific antibody that targets PDCD1 (PD-1) and VEGF, which potentially decreases tumor growth (Journal for ImmunoTherapy of Cancer 2025;13, Suppl_3).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SSGJ-707 PF-08634404|SSGJ 707|SSGJ707|PF08634404|PF 08634404 PD-L1/PD-1 antibody 137 VEGF Antibody 17 SSGJ-707 (PF-08634404) is a bispecific antibody that targets PDCD1 (PD-1) and VEGF, which potentially decreases tumor growth (Journal for ImmunoTherapy of Cancer 2025;13, Suppl_3).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT07476287 Phase II SSGJ-707 Symbiotic-Lung-14: A Study to Learn About the Study Medicine Called PF08634404 in Combination With Chemotherapy in Adult Participants With Transformed Small Cell Lung Cancer Recruiting USA 1
NCT07392892 Phase II SSGJ-707 Nivolumab A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer Recruiting USA 1
NCT07222566 Phase III SSGJ-707 Pembrolizumab Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Recruiting USA | TUR | ISR | FRA | ESP | CZE | CAN | AUS | ARG 5
NCT07227012 Phase Ib/II SSGJ-707 Ipilimumab + SSGJ-707 Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body. Recruiting USA 3
NCT07226999 Phase II Atezolizumab SSGJ-707 Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer Recruiting USA | FRA | ESP | AUS 3
NCT07222800 Phase III SSGJ-707 Bevacizumab Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer Recruiting USA | POL | ITA | ISR | FRA | ESP | DEU | CAN | BRA | BEL | AUS 3
NCT07421700 Phase Ib/II Enfortumab vedotin-ejfv + SSGJ-707 SSGJ-707 Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer Recruiting USA | AUS 2
NCT07227298 Phase Ib/II SSGJ-707 SGN-B6A + SSGJ-707 Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers Recruiting USA 3
NCT07227415 Phase Ib/II SSGJ-707 Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer Recruiting USA | AUS 1


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