Therapy Detail
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| Therapy Name | IDE397 + IDE892 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| IDE397 | IDE-397|IDE 397 | MAT2A Inhibitor 5 | IDE397 inhibits MAT2A, which may reduce synthesis of S-adenosyl-L-methionine (SAM), potentially leading to anti-tumor activity in MTAP-deficient cancers (Cancer Res 2021;81(13_Suppl):Abstract nr 1278). | |
| IDE892 | IDE-892|IDE 892 | PRMT5 Inhibitor 22 | Limited information is currently available on IDE892, a putative PRMT5 inhibitor (Jan 2026). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07277413 | Phase I | IDE892 IDE397 + IDE892 | A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors | Recruiting | USA | 0 |
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