Therapy Detail
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| Therapy Name | CC-92480 + Ziftomenib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CC-92480 | CELMoD CC92480|CC 92480|Mezigdomide|BMS-986348|BMS986348|BMS 986348 | CC-92480 binds to and modulates activity of the ubiquitin E3 ligase complex member Cereblon (CRBN), which may induce ubiquitination and degradation of transcription factors in T-lymphocytes, resulting in immune system activation (Blood (2019) 134 (Supplement_1): 1812, PMID: 32130004). | ||
| Ziftomenib | Komzifti | KO539|KO 539|KO-539 | MEN1-KMT2A Inhibitor 8 | Komzifti (ziftomenib) is a small molecule inhibitor of MEN1 (menin)-KMT2A (MLL1) complex, which may lead to decreased growth KMT2A (MLL1)-positive tumor cells, and inhibition of tumor growth (PMID: 36151141). Komzifti (ziftomenib) is FDA-approved for use in patients with relapsed/refractory acute myeloid leukemia harboring a susceptible NPM1 mutation (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07355335 | Phase I | CC-92480 + Ziftomenib | Ziftomenib + Mezigdomide in Adolesc. and Adults w/ R/R AML | Not yet recruiting | USA | 0 |
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