Therapy Detail
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| Therapy Name | Cetuximab + TROP2 CAR/IL-15 TGFBR2 KO NK cells |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cetuximab | Erbitux | IMC-C225 | EGFR Antibody 74 | Erbitux (cetuximab) is a monoclonal antibody directed against EGFR, which inhibits signal transduction and cell proliferation (PMID: 28695301). Erbitux (cetuximab) is FDA-approved for use in head and neck squamous cell carcinoma and KRAS wild-type, EGFR-positive colorectal cancer, and in combination with Braftovi (encorafenib) with or without mFOLFOX6 in patients with metastatic colorectal cancer with BRAF V600E (FDA.gov). |
| TROP2 CAR/IL-15 TGFBR2 KO NK cells | Allogeneic anti-TROP2-CAR-IL-15-transduced TGFBR2-KO CB-derived NKs | TROP2 CAR/IL-15 TGFBR2 KO NK cells are allogeneic, umbilical cord blood-derived natural killer cells engineered to express a chimeric antigen receptor (CAR) targeting TROP2 and with TGFBR2 deleted, which may lead to enhanced anti-tumor response (NCI Thesaurus). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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