Therapy Detail
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| Therapy Name | BBO-11818 + Gemcitabine + Nab-paclitaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BBO-11818 | BBO 11818|BBO11818 | KRAS G12D Inhibitor 25 KRAS Inhibitor 31 | BBO-11818 is a selective pan-KRAS inhibitor with activity against KRAS variants including G12D and G12V, potentially leading to decreased tumor cell proliferation and reduced tumor growth (Cancer Res (2025) 85 (8_Supplement_1): 4378). | |
| Gemcitabine | Gemzar | Difluorodeoxycytidine Hydrochlorothiazide|LY-188011 | Chemotherapy - Antimetabolite 14 | Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary). |
| Nab-paclitaxel | Abraxane | ABI-007|Paclitaxel Protein-bound | Chemotherapy - Taxane 3 | Abraxane (nab-paclitaxel) is an albumin-stablized version of paclitaxel, which binds microtubules and prevents depolymerization, resulting in decreased cell motility and division (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06917079 | Phase I | BBO-11818 + Pembrolizumab BBO-11818 + Cisplatin + Pembrolizumab + Pemetrexed Disodium BBO-11818 + Carboplatin + Pembrolizumab + Pemetrexed Disodium BBO-11818 + Cetuximab + Fluorouracil + Leucovorin + Oxaliplatin BBO-11818 + Cetuximab BBO-11818 + Fluorouracil + Leucovorin + Liposomal irinotecan + Oxaliplatin BBO-11818 BBO-11818 + Gemcitabine + Nab-paclitaxel | BBO-11818 in Adult Subjects With KRAS Mutant Cancer | Recruiting | USA | 0 |
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