Therapy Detail
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| Therapy Name | AZD0305 + Dexamethasone + Pomalidomide |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AZD0305 | AZD-0305|AZD 0305 | AZD0305 is an antibody-drug conjugate (ADC) targeting GPRC5D, which potentially induces antibody-dependent cellular cytotoxicity in tumor cells expressing GPRC5D (Blood (2024) 144 (Supplement 1): 2000.2). | ||
| Dexamethasone | Adexone | Desametasone | ||
| Pomalidomide | Pomalyst | CC-4047 | Pomalyst (pomalidomide) is a thalidomide derivative that inhibits angiogenesis and modulates immune response, potentially lead to antitumor activity (PMID: 30069630). Pomalyst (pomalidomide) is FDA approved for use in patients with Kaposi's sarcoma who failed HAART or are HIV-negative, and in combination with dexamethasone in patients with multiple myeloma who had 2 or more prior therapies (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06106945 | Phase Ib/II | AZD0305 + Elranatamab-bcmm AZD0305 + Dexamethasone + Pomalidomide AZD0305 | AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple Myeloma | Recruiting | USA | FRA | ESP | DEU | CAN | AUS | 2 |
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