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Therapy Name NPM1c CAR-T cells
Synonyms
Therapy Description

NPM1c CAR-T cells are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets HLA-A*02:01-binding NPM1 C-terminal mutations, which may lead to killing of NPM1-mutant tumor cells (PMID: 38516690, PMID: 30640174).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
NPM1c CAR-T cells BSB-2002|BSB 2002|BSB2002 NPM1c CAR-T cells are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets HLA-A*02:01-binding NPM1 C-terminal mutations, which may lead to killing of NPM1-mutant tumor cells (PMID: 38516690, PMID: 30640174).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT07583303 Phase I Cyclophosphamide + Fludarabine NPM1c CAR-T cells BSB-2002 After Cyclophosphamide and Fludarabine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Patients With NPM1 Mutation Not yet recruiting USA 0
NCT07566585 Phase I NPM1c CAR-T cells Dose Finding Study to Evaluate the Safety of BSB-2002 in Relapsed or Refractory Acute Myeloid Leukemia (AML) Patients With NPM1 Mutation Recruiting USA 0


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