Therapy Detail
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| Therapy Name | BGB-58067 + Temozolomide |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BGB-58067 | BGB58067|BGB 58067 | PRMT5 Inhibitor 21 | BGB-58067 selectively inhibits PRMT5 in MTAP-deleted cells, which potentially leads to decreased tumor cell growth (Cancer Res (2025) 85 (8_Supplement_2): CT193, NCI Drug Dictionary). | |
| Temozolomide | Temodar | Methazolastone|TMZ | Chemotherapy - Alkylating 18 | Temodar (temozolomide) is a dacarbazine analog and cytotoxic alkylating agent (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07485049 | Phase I | BGB-58067 + Temozolomide BGB-58067 | BGB-58067 in Newly Diagnosed Glioblastoma Patients With MTAP-Deleted Tumors | Recruiting | USA | 0 |
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