Therapy Detail
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| Therapy Name | 4A10 |
| Synonyms | |
| Therapy Description |
4A10 is a monoclonal antibody targeting CD127, which potentially inhibits IL-7 signaling and induces antibody-dependent cellular cytotoxicity and phagocytosis and inhibits tumor cell proliferation (Cancer Res (2025) 85 (8_Supplement_1): 7044). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| 4A10 | 4-A10|4A-10 | 4A10 is a monoclonal antibody targeting CD127, which potentially inhibits IL-7 signaling and induces antibody-dependent cellular cytotoxicity and phagocytosis and inhibits tumor cell proliferation (Cancer Res (2025) 85 (8_Supplement_1): 7044). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07586618 | Phase I | 4A10 | First-in-human Study of a New Treatment (4A10) for Patients With Relapsed or Hard-to-treat Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma, Focused on Safety and How the Drug Behaves in the Body and Early Signs of Effect. (ALT-101) | Recruiting | USA | 0 |
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