Therapy Detail
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| Therapy Name | p95HER2.CAR-TECH2Me T-cells |
| Synonyms | |
| Therapy Description |
p95HER2.CAR-TECH2Me T-cells are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting p95HER2 and a trastuzumab-based bispecific antibody targeting ERBB2 (HER2), which potentially inhibit tumor growth of ERBB2 (HER2)-driven tumors (PMID: 39557820). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| p95HER2.CAR-TECH2Me T-cells | p95HER2.CAR-TECH2Me-T cells|p95HER2 CAR TECH2Me T-cells | HER2 (ERBB2) Immune Cell Therapy 10 | p95HER2.CAR-TECH2Me T-cells are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting p95HER2 and a trastuzumab-based bispecific antibody targeting ERBB2 (HER2), which potentially inhibit tumor growth of ERBB2 (HER2)-driven tumors (PMID: 39557820). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07593820 | Phase I | p95HER2.CAR-TECH2Me T-cells Cyclophosphamide + Fludarabine | A Phase I Interventional Open-label, Non-randomized Dose-escalation Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity, and Preliminary Anti-tumor Activity of Autologous p95HER2.CAR-TECH2Me T Cells in Patients With Selected Advanced Cancers. (Catherine) | Recruiting | ESP | 0 |
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