Therapy Detail
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| Therapy Name | AZD5335 + AZD9574 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AZD5335 | AZD 5335|AZD-5335|Torvutatug Samrotecan | FOLR1-targeted Therapy 24 | AZD5335 is an antibody-drug conjugate (ADC) comprising an antibody targeting FOLR1 (FRalpha) linked to a topoisomerase 1 inhibitor, which potentially inhibits tumor growth (Cancer Res (2023) 83 (8_Supplement): LB025). | |
| AZD9574 | AZD-9574|AZD 9574 | PARP-1 Inhibitor 13 | AZD9574 is a PARP1 inhibitor that can penetrate the blood-brain barrier, potentially leading to inhibition of tumor growth (PMID: 37967136). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05797168 | Phase Ib/II | AZD5335 + Pembrolizumab AZD5335 + Bevacizumab + Carboplatin AZD5335 + Saruparib AZD5335 + Bevacizumab AZD5335 AZD5335 + AZD9574 + Pembrolizumab AZD5335 + AZD9574 AZD5335 + AZD9574 + Bevacizumab AZD5335 + Carboplatin | Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors (FONTANA) | Recruiting | USA | TUR | ISR | GBR | ESP | DEU | CAN | AUS | 4 |
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