Therapy Detail
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| Therapy Name | CC-92480 + Dexamethasone + KTX-1001 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CC-92480 | CELMoD CC92480|CC 92480|Mezigdomide|BMS-986348|BMS986348|BMS 986348 | CC-92480 binds to and modulates activity of the ubiquitin E3 ligase complex member Cereblon (CRBN), which may induce ubiquitination and degradation of transcription factors in T-lymphocytes, resulting in immune system activation (Blood (2019) 134 (Supplement_1): 1812, PMID: 32130004). | ||
| Dexamethasone | Adexone | Desametasone | ||
| KTX-1001 | KTX 1001|KTX1001 | KTX-1001 is a selective inhibitor of NSD2 (MMSET), which potentially inhibits tumor cell growth and induces antitumor activity (Blood (2024) 144 (Supplement 1): 3370, NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05651932 | Phase I | KTX-1001 CC-92480 + Dexamethasone + KTX-1001 Dexamethasone + KTX-1001 Dexamethasone + KTX-1001 + Pomalidomide Carfilzomib + Dexamethasone + KTX-1001 | A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma | Recruiting | USA | FRA | ESP | CAN | 0 |
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