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Therapy Name ITI-5000
Synonyms
Therapy Description

ITI-5000 is a self-amplifying RNA vaccine that encodes the tumor-associated antigens HERV-K and CT-83, which potentially activates CD4+ and CD8+ T-cells to induce antitumor immune response (Journal for ImmunoTherapy of Cancer 2024:12).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ITI-5000 ITI5000|ITI 5000 ITI-5000 is a self-amplifying RNA vaccine that encodes the tumor-associated antigens HERV-K and CT-83, which potentially activates CD4+ and CD8+ T-cells to induce antitumor immune response (Journal for ImmunoTherapy of Cancer 2024:12).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT07652242 Phase I ITI-5000 ITI-5000 + Pembrolizumab First-in-human, Phase 1 Study of a Self-amplifying RNA Vaccine (ITI-5000) Alone or in Combination With Pembrolizumab in Stage II-- III Triple Negative Breast Cancer Following Standard Therapy ( VITAL-TNBC ) (VITAL-TNBC) Recruiting USA 0


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