Therapy Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Therapy Name | BYS10 |
| Synonyms | |
| Therapy Description |
BYS10 is a third-generation RET inhibitor, which potentially inhibits Ret kinase activity and tumor growth (PMID: 41181595). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BYS10 | BYS-10|BYS 10 | RET Inhibitor 54 | BYS10 is a third-generation RET inhibitor, which potentially inhibits Ret kinase activity and tumor growth (PMID: 41181595). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET mutant | medullary thyroid carcinoma | predicted - sensitive | BYS10 | Case Reports/Case Series | Actionable | In a Phase I/II trial, treatment with BYS10 resulted in an objective response rate (ORR) of 62.5% and disease control rate (DCR) of 85% in advanced solid tumors (n=40), with an ORR of 50% and DCR of 100% in patients with medullary thyroid cancer harboring a RET mutation (n=4) (J Clin Oncol 2025 43: 16_suppl, 8601). | detail... |
| RET fusion | thyroid cancer | predicted - sensitive | BYS10 | Case Reports/Case Series | Actionable | In a Phase I/II trial, treatment with BYS10 resulted in an objective response rate (ORR) of 62.5% and disease control rate (DCR) of 85% in advanced solid tumors (n=40), with an ORR of 83.3% and DCR of 100% in patients with thyroid cancer harboring a RET fusion (n=6) (J Clin Oncol 2025 43: 16_suppl, 8601). | detail... |
| RET fusion | lung non-small cell carcinoma | predicted - sensitive | BYS10 | Phase Ib/II | Actionable | In a Phase I/II trial, treatment with BYS10 resulted in an objective response rate (ORR) of 62.5% and disease control rate (DCR) of 85% in advanced solid tumors (n=40), with an ORR of 60% and DCR of 80% in patients with non-small cell lung cancer harboring a RET fusion (n=30) (J Clin Oncol 2025 43: 16_suppl, 8601). | detail... |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
CKB BOOST