Therapy Detail
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| Therapy Name | Bevacizumab + MRG007 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bevacizumab | Avastin | VEGF Antibody 17 VEGFR Inhibitor (Pan) 36 | Avastin (bevacizumab) is a monoclonal antibody that binds VEGF and inhibits binding to VEGFR, potentially resulting in decreased tumor growth (PMID: 15136787). Avastin (bevacizumab) is FDA approved for use in colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, cervical carcinoma, and ovarian cancer, and in combination with carboplatin and paclitaxel in epithelial ovarian, fallopian tube, or primary peritoneal cancer (FDA.gov). | |
| MRG007 | MRG-007|MRG 007|ARR-217|ARR217|ARR 217 | MRG007 is an antibody-drug conjugate (ADC) comprising an antibody targeting CDH17 conjugated to exatecan, which potentially inhibits growth of CDH17-expressing tumors (Cancer Res (2025) 85 (8_Supplement_1): 2877). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07066657 | Phase I | MRG007 Bevacizumab + MRG007 | A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors | Recruiting | USA | 1 |
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