Therapy Detail
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| Therapy Name | Fruquintinib |
| Synonyms | |
| Therapy Description |
Fruzaqla (fruquintinib) binds and inhibits VEGFR1/2/3, potentially resulting in reduced cell proliferation and decreased tumor growth (PMID: 25482937, PMID: 31790382). Fruzaqla (fruquintinib) is FDA approved for use in patients with metastatic colorectal cancer who have received prior therapy (FDA.gov). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Fruquintinib | Fruzaqla | HMPL-013 | VEGFR Inhibitor (Pan) 36 | Fruzaqla (fruquintinib) binds and inhibits VEGFR1/2/3, potentially resulting in reduced cell proliferation and decreased tumor growth (PMID: 25482937, PMID: 31790382). Fruzaqla (fruquintinib) is FDA approved for use in patients with metastatic colorectal cancer who have received prior therapy (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03251378 | Phase I | Fruquintinib | The Evaluation of Safety, Tolerability, and Pharmacokinetics for Fruquintinib in Solid Tumors | Completed | USA | 0 |
| NCT04322539 | Phase III | Fruquintinib | A Study of Efficacy and Safety of Fruquintinib (HMPL-013) in Patients With Metastatic Colorectal Cancer (FRESCO-2) | Completed | USA | POL | ITA | HUN | GBR | FRA | EST | ESP | DEU | CZE | BEL | AUT | AUS | 1 |
| NCT07130903 | Phase II | Fruquintinib | Amplitude-Modulated Radiofrequency Electromagnetic Fields (AM RF EMF) in Combination With Fruquintinib in Refractory Metastatic Colorectal Cancer | Recruiting | USA | 0 |
| NCT07235293 | Phase II | Fruquintinib Atezolizumab + DSP107 | A Study to Test DSP107 in Combination With Atezolizumab in Comparison With Fruquintinib as a New Treatment for Colorectal Cancer. | Not yet recruiting | USA | AUS | 0 |
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