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Therapy Name	CBX-663
Synonyms
Therapy Description	CBX-663 is a T-cell receptor (TCR) mimetic T-cell engager comprising a CD3-binding domain and two TCR domains targeting TERT and HLA-A*02:01, which potentially induces T cell-mediated cytotoxicity and inhibits tumor growth (Cancer Res (2026) 86 (7_Supplement): 1635).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
CBX-663		CBX663\|CBX 663		CBX-663 is a T-cell receptor (TCR) mimetic T-cell engager comprising a CD3-binding domain and two TCR domains targeting TERT and HLA-A*02:01, which potentially induces T cell-mediated cytotoxicity and inhibits tumor growth (Cancer Res (2026) 86 (7_Supplement): 1635).

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Case insensitive filtering will display rows if any text in any cell matches the filter term
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Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References

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Case insensitive filtering will display rows if any text in any cell matches the filter term
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Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT07779798	Phase I	CBX-663	A Phase 1, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Clinical Activity of CBX-663 in Participants With Relapsed or Refractory Myeloid Malignancies, Advanced Solid Tumors, or Recurrent or Progressive Glioblastoma. (TelOscope)	Not yet recruiting	USA	0

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