Therapy Detail
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| Therapy Name | Doxorubicin + FP-1305 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Doxorubicin | Adriamycin | Adria|ADR|Doxorubicin hydrochloride|Hydroxydaunorubicin | Chemotherapy - Anthracycline 13 TOPO2 inhibitor 5 | Adriamycin (doxorubicin) is an anthracycline chemotherapeutic, in a non-liposomal formulation, which intercalates into DNA and inhibits topoisomerase II (PMID: 24367159). Doxorubicin is FDA approved for multiple cancer types (FDA.gov). |
| FP-1305 | FP1305|FP 1305|Clevegen|Bexmarilimab | FP-1305 is a humanized IgG4 antibody that targets the scavenger receptor Clever-1 on tumor-associated macrophages, which may lead to immune cell activation and tumor growth inhibition (PMID: 34078651). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07460986 | Phase Ib/II | Doxorubicin + FP-1305 Doxorubicin | A Phase Ib/II Study to Evaluate Safety and Efficacy of Bexmarilimab in Combination With Doxorubicin in Metastatic Soft-tissue Sarcoma. (BEXAR) | Recruiting | ESP | 0 |
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