Therapy Detail
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| Therapy Name | Doxorubicin + DT-7012 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| DT-7012 | DT 7012|DT7012 | CCR8 Antibody 13 | DT-7012 is a monoclonal antibody targeting CCR8, which potentially induces antibody-dependent cellular cytotoxicity (ADCC) and depletion of CCR8-positive regulatory T-cells (Cancer Res (2025) 85 (8_Supplement_1): 312). | |
| Doxorubicin | Adriamycin | Adria|ADR|Doxorubicin hydrochloride|Hydroxydaunorubicin | Chemotherapy - Anthracycline 13 TOPO2 inhibitor 5 | Adriamycin (doxorubicin) is an anthracycline chemotherapeutic, in a non-liposomal formulation, which intercalates into DNA and inhibits topoisomerase II (PMID: 24367159). Doxorubicin is FDA approved for multiple cancer types (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07802652 | Phase II | Doxorubicin Doxorubicin + DT-7012 | A Randomized Phase II Study of Doxorubicin With or Without DT-7012 in Advanced Soft Tissue Sarcoma (IMMUSARC-7012) | Not yet recruiting | FRA | 0 |
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