Therapy Detail
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| Therapy Name | FHD-286 + Quizartinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| FHD-286 | FHD286|FHD 286 | FHD-286 inhibits SMARCA4 (BRG1) and SMARCA2 (BRM), which may lead to altered chromatin accessibility and decreased tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr ND14, PMID: 38437498). | ||
| Quizartinib | Vanflyta | AC220 | FLT3 Inhibitor 69 | Vanflyta (quizartinib) is a small molecule that selectively inhibits FLT3, which may induce apoptosis and inhibit tumor growth (PMID: 19654408, PMID: 23497317). Vanflyta (quizartinib) is FDA-approved for use in combination with standard cytarabine and anthracycline induction and cytarabine consolidation, and as maintenance monotherapy following consolidation chemotherapy, in patients with newly diagnosed acute myeloid leukemia harboring FLT3 ITD mutations (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KMT2A rearrange FLT3 exon 14 ins FLT3 D835Y | acute myeloid leukemia | sensitive | FHD-286 + Quizartinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, FHD-286 and Vanflyta (quizartinib) synergistically inhibited viability in acute myeloid leukemia cells harboring a KMT2A rearrangement, FLT3-ITD, and FLT3 D835Y in culture, and resulted in increased survival compared to treatment with Vanflyta (quizartinib) alone in a cell line xenograft model (PMID: 40089460). | 40089460 |
| KMT2A rearrange FLT3 exon 14 ins | acute myeloid leukemia | sensitive | FHD-286 + Quizartinib | Preclinical - Cell culture | Actionable | In a preclinical study, FHD-286 and Vanflyta (quizartinib) synergistically inhibited viability in acute myeloid leukemia cells harboring KMT2A rearrangements and FLT3-ITD in culture (PMID: 40089460). | 40089460 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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