Therapy Detail
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| Therapy Name | Gemcitabine + KST-6051 + Nab-paclitaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Gemcitabine | Gemzar | Difluorodeoxycytidine Hydrochlorothiazide|LY-188011 | Chemotherapy - Antimetabolite 14 | Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary). |
| KST-6051 | KST6051|KST 6051 | KRAS Inhibitor 34 | Limited information is currently available on KST-6051, a putative pan-KRAS inhibitor (Apr 2026). | |
| Nab-paclitaxel | Abraxane | ABI-007|Paclitaxel Protein-bound | Chemotherapy - Taxane 3 | Abraxane (nab-paclitaxel) is an albumin-stablized version of paclitaxel, which binds microtubules and prevents depolymerization, resulting in decreased cell motility and division (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07458347 | Phase I | Cetuximab + Fluorouracil + KST-6051 + Leucovorin + Oxaliplatin Cetuximab + Fluorouracil + Irinotecan + KST-6051 + Leucovorin KST-6051 Cetuximab + KST-6051 KST-6051 + Pembrolizumab Carboplatin + KST-6051 + Pembrolizumab + Pemetrexed Disodium Gemcitabine + KST-6051 + Nab-paclitaxel | A Phase 1 Dose Escalation and Dose Expansion Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation | Recruiting | USA | 0 |
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