Therapy Detail
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| Therapy Name | CR-001 + Paclitaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CR-001 | CR001|CR 001 | PD-L1/PD-1 antibody 139 VEGF Antibody 18 | CR-001 is a tetravalent bispecific antibody targeting PDCD1 (PD-1) and VEGF, which potentially induces antitumor immune activity (Journal for ImmunoTherapy of Cancer 2025;13, Suppl_2, 1185). | |
| Paclitaxel | Taxol | 7-Epipaclitaxel | Antimicrotubule Agent 14 BCL2 Family Inhibitor 6 | Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07335497 | Phase Ib/II | Cisplatin + CR-001 + Gemcitabine Capecitabine + CR-001 + Oxaliplatin CR-001 + Paclitaxel CR-001 + Fluorouracil + Leucovorin + Oxaliplatin CR-001 + Trifluridine-tipiracil hydrochloride Carboplatin + CR-001 + Paclitaxel CR-001 Carboplatin + CR-001 + Pemetrexed Disodium | CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors (ASCEND) | Recruiting | USA | ROU | ITA | IRL | GBR | FRA | ESP | AUS | 1 |
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