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Therapy Name | Medroxyprogesterone |
Synonyms | |
Therapy Description |
Depo-Provera (medroxyprogesterone) is a synthetic progesterone derivative that acts as an anti-estrogen by binding to and activating nuclear receptors, stimulating downstream signaling and potentially resulting in decreased growth of estrogen-sensitive tumor cells (NCI Drug Dictionary). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Medroxyprogesterone | Depo-Provera | CBP-1011 | Hormone - Anti-estrogens 30 | Depo-Provera (medroxyprogesterone) is a synthetic progesterone derivative that acts as an anti-estrogen by binding to and activating nuclear receptors, stimulating downstream signaling and potentially resulting in decreased growth of estrogen-sensitive tumor cells (NCI Drug Dictionary). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT02335203 | Phase II | Medroxyprogesterone | The Effect of Neoadjuvant DMPA on Glandular Cellularity in Women Awaiting Hysterectomy | Unknown status | USA | 0 |
NCT03018249 | Phase II | Medroxyprogesterone Entinostat + Medroxyprogesterone | Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer | Completed | USA | 0 |
NCT05255653 | Phase II | Olaparib Medroxyprogesterone Carboplatin Megestrol acetate Paclitaxel Cisplatin Durvalumab | Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features (RAINBO) | Recruiting | NLD | GBR | FRA | CAN | 0 |
NCT02228681 | Phase II | Tamoxifen Medroxyprogesterone Everolimus + Letrozole | Everolimus and Letrozole or Hormonal Therapy to Treat Endometrial Cancer | Completed | USA | 0 |