Therapy Detail
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| Therapy Name | GNF-4256 |
| Synonyms | |
| Therapy Description |
GNF-4256 inhibits TRK receptor activation, potentially resulting in decreased tumor growth (PMID: 25394774). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| GNF-4256 | Trk Receptor Inhibitor (Pan) 33 | GNF-4256 inhibits TRK receptor activation, potentially resulting in decreased tumor growth (PMID: 25394774). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NTRK2 loss | neuroblastoma | no benefit | GNF-4256 | Preclinical | Actionable | In a preclinical study, GNF-4256 treatment had no effect on the growth of Ntrk2-null neuroblastoma cell lines in culture (PMID: 25394774). | 25394774 |
| NTRK2 positive | neuroblastoma | sensitive | GNF-4256 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, GNF-4256 treatment inhibited BDNF-induced phosphorylation of Ntrk2 and growth of neuroblastoma cell lines expressing Ntrk2 in culture, and slowed tumor growth in the neuroblastoma cell line xenograft models (PMID: 25394774). | 25394774 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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